ETHYL 4-ETHOXYPHENYLACETATE
ETHYL 4-ETHOXYPHENYLACETATE
CAS: 40784-88-1
Molecular Formula: C12H16O3
ETHYL 4-ETHOXYPHENYLACETATE - Names and Identifiers
| Name | ETHYL 4-ETHOXYPHENYLACETATE |
| Synonyms | ETHYL 4-ETHOXYPHENYLACETATE ethyl 2-(4-ethoxyphenyl)acetate 4-Ethoxyphenylacetic acid ethyl ester |
| CAS | 40784-88-1 |
ETHYL 4-ETHOXYPHENYLACETATE - Physico-chemical Properties
| Molecular Formula | C12H16O3 |
| Molar Mass | 208.26 |
| Boling Point | 112-113°C 0,5mm |
| Flash Point | 112-113°C/0.5mm |
| Storage Condition | Room Temprature |
| Refractive Index | 1.5020 |
| MDL | MFCD00051917 |
| Physical and Chemical Properties | The chemical product is a white solid, m.p.47 ℃, B. p.150 ~ 151 ℃/1.5kpa, soluble in benzene and toluene, insoluble in water. |
| Use | Use ethyl p-ethoxyphenyl acetate is an intermediate for the preparation of cypermethrin. |
ETHYL 4-ETHOXYPHENYLACETATE - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
ETHYL 4-ETHOXYPHENYLACETATE - Upstream Downstream Industry
ETHYL 4-ETHOXYPHENYLACETATE - Production method
the preparation method can use phenylethyl ether as raw material, saturate with hydrogen chloride in concentrated hydrochloric acid and benzene solution, then add cold formaldehyde aqueous solution, continue to pass hydrogen chloride, stir the mixture at room temperature for 2 hours, chloromethylation of phenylethyl ether, separation of the reaction liquid into water layer and benzene layer, washing with NaHCO3 solution to neutral, drying, and evaporating benzene under reduced pressure to obtain. The mixture is an unstable compound that cannot be separated. Further cyanidation is carried out. In the sodium cyanide aqueous solution, acetone and tetrabutylammonium bromide are added as the phase transfer catalyst, and then o-and p-ethoxybenzyl chloride are added. Stir vigorously at 56°C for 6 hours, cool and add water, divide the water layer, wash the oil layer to neutral, it is an orange-yellow liquid, which is o-and p-eth, to get p-ethoxy cyanobenzyl.
p-ethoxycyanobenzyl is added to the ethylene glycol solution containing potassium hydroxide, heated and stirred, cooled to room temperature, acidified, added water and benzene, extracted with benzene p-ethoxyphenylacetic acid, and then distilled to remove benzene to obtain p-ethoxyphenylacetic acid, and further esterified with absolute ethanol in the presence of an acid catalyst to obtain p-ethoxyphenylacetate.
It is also possible to use p-methylphenol as a raw material, first etherify with diethyl sulfate to generate p-methylphenylethyl ether, and further chlorinate to obtain p-ethoxybenzyl chloride, and then cyanide with sodium cyanide in the presence of a phase transfer catalyst To obtain p-ethoxycyanobenzyl, which is then hydrolyzed to produce p-ethoxyphenylacetic acid, and esterified to obtain ethyl p.
It is also possible to use p-ethoxyacetophenone to react with sodium hydroxide in the presence of piperazine sulfide, the reaction temperature is 135~140 ℃, the reaction is 20h, the reaction is over, the cooling post-treatment can also be used to prepare p-ethoxyphenylacetic acid, and then to further prepare ethyl p-ethoxyphenylacetate.
Last Update：2024-04-10 22:29:15
ETHYL 4-ETHOXYPHENYLACETATE - Nature
| BRN | 2969074 |
Last Update：2024-04-09 19:04:55
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View History
Raw Materials for ETHYL 4-ETHOXYPHENYLACETATE
Hydrochloric acid
Potassium hydroxide
Piperazine
Tetrabutylammonium bromide
formaldehyde
Diethyl sulfate
Phenetole
Potassium hydroxide
Piperazine
Tetrabutylammonium bromide
formaldehyde
Diethyl sulfate
Phenetole
Downstream Products for ETHYL 4-ETHOXYPHENYLACETATE